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Updated: May 5, 2026

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A Bidirectional Mendelian Randomization Study of the Causal Association Between Ischemic Stroke, Coronary Heart

Wencai Wang1, Menghao Liu1, Zun Wang1

  • 1Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.

Brain and Behavior
|October 8, 2024
PubMed

Insights

Coronary heart disease and ischemic stroke may increase the risk of developing hydrocephalus. This Mendelian randomization study used genetic data to explore the causal link between these conditions.

Area of Science:

  • Cardiovascular epidemiology
  • Neurology
  • Genetic epidemiology

Background:

  • The relationship between coronary heart disease (CHD), ischemic stroke (IS), and hydrocephalus is not well understood.
  • Further research is needed to clarify potential causal links.

Purpose of the Study:

  • To investigate the causal relationship between coronary heart disease, ischemic stroke, and hydrocephalus using a Mendelian randomization approach.
  • To assess whether CHD and IS are risk factors for hydrocephalus.

Main Methods:

  • Utilized genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with CHD and IS.
  • Employed five Mendelian randomization methods (IVW, MR-Egger, Weighted Median, Weighted mode, Simple mode) to analyze the causal effects.

Main Results:

  • Inverse variance weighted (IVW) analysis indicated that both ischemic stroke (OR=1.650) and coronary heart disease (OR=1.307) are risk factors for hydrocephalus.
  • MR-Egger intercept and Cochran's Q tests supported the reliability of the IVW results.
  • No evidence of reverse causation was found, suggesting hydrocephalus does not cause CHD or IS.

Conclusions:

  • Coronary heart disease and ischemic stroke may contribute to an increased risk of developing hydrocephalus.
  • Findings suggest a potential etiological role for cardiovascular and cerebrovascular diseases in hydrocephalus development.
Abstract

Keywords:
Mendelian randomizationcoronary heart diseasegenetichydrocephalusischemic stroke

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