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Updated: Jun 11, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
RESOLUTION OF MACULAR CONFLUENT DRUSEN DURING THE DEVELOPMENT AND SPONTANEOUS CLOSURE OF AN ECCENTRIC FULL-THICKNESS
Shuichiro Aoki1, Kohei Ueda, Kohdai Kitamoto
1Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan .
Purpose:
The objective of this study was to describe a unique case of drusen resolution accompanying the spontaneous closure of an eccentric full-thickness macular hole.
Methods:
This study is a case report.
Results:
A 71-year-old man exhibited confluent drusen in the right eye beneath the fovea. During regular follow-up, an eccentric full-thickness macular hole developed in the right eye and closed spontaneously. Concurrently, the confluent drusen showed rapid regression without signs of geographic atrophy or macular neovascularization. Visual acuity remained stable throughout the monitoring period.
Conclusion:
This case suggests that drusen regression can occur alongside spontaneous full-thickness macular hole closure without surgical intervention. This adds to the current understanding of the pathology and treatment of drusen.
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