Role of TREM2 in immune and neurological diseases: Structure, function, and implications
Peng Yin1, Zhaoliang Su2, Xiaozheng Shu3
1International Genome Center, Jiangsu University, Zhenjiang 212013, China.
International Immunopharmacology
|October 8, 2024
Summary
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is vital in neuroprotection, obesity, and cancer. This review details TREM2
Area of Science:
- Immunology
- Neuroscience
- Oncology
Background:
- Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor.
- Initially associated with neurodegenerative diseases.
- Emerging roles in obesity and cancer.
Purpose of the Study:
- Review the structure, function, and mechanisms of TREM2.
- Focus on TREM2's roles in immune regulation and neuroprotection.
- Discuss the therapeutic potential of targeting TREM2.
Main Methods:
- Literature review of TREM2's function.
- Analysis of TREM2's role in diverse pathological contexts.
- Exploration of TREM2 signaling pathways.
Main Results:
- TREM2 modulates cellular activity via ligand binding.
- TREM2 activation triggers downstream signaling.
- TREM2 exerts significant immunomodulatory effects.
Conclusions:
- TREM2 is a key regulator in neuroprotection, immunity, obesity, and cancer.
- Targeting TREM2 presents a promising therapeutic strategy.
- Further research into TREM2 mechanisms is warranted.
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