Related Experiment Video

Updated: Jun 11, 2025

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

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Role of TREM2 in immune and neurological diseases: Structure, function, and implications

Peng Yin1, Zhaoliang Su2, Xiaozheng Shu3

  • 1International Genome Center, Jiangsu University, Zhenjiang 212013, China.

International Immunopharmacology
|October 8, 2024
PubMed

Insights

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is vital in neuroprotection, obesity, and cancer. This review details TREM2

Area of Science:

  • Immunology
  • Neuroscience
  • Oncology

Background:

  • Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor.
  • Initially associated with neurodegenerative diseases.
  • Emerging roles in obesity and cancer.

Purpose of the Study:

  • Review the structure, function, and mechanisms of TREM2.
  • Focus on TREM2's roles in immune regulation and neuroprotection.
  • Discuss the therapeutic potential of targeting TREM2.

Main Methods:

  • Literature review of TREM2's function.
  • Analysis of TREM2's role in diverse pathological contexts.
  • Exploration of TREM2 signaling pathways.

Main Results:

  • TREM2 modulates cellular activity via ligand binding.
  • TREM2 activation triggers downstream signaling.
  • TREM2 exerts significant immunomodulatory effects.

Conclusions:

  • TREM2 is a key regulator in neuroprotection, immunity, obesity, and cancer.
  • Targeting TREM2 presents a promising therapeutic strategy.
  • Further research into TREM2 mechanisms is warranted.
Keywords:
Immune regulationMacrophageNervous systemTREM2

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