Plasma Inclusive Resuscitation Is Not Associated With Coagulation Profile Changes in Burn Patients.

Area of Science:

• Trauma and Emergency Medicine
• Burn Care and Resuscitation
• Coagulation and Hemostasis

Background:

• Crystalloids are standard for burn shock resuscitation.
• Concerns exist regarding plasma's potential negative effects on coagulation and inflammation.
• Plasma-inclusive resuscitation (PIR) was investigated as an alternative approach.

Purpose of the Study:

• To evaluate if plasma-inclusive resuscitation (PIR) in burn patients is associated with prothrombotic changes.
• To compare coagulation and inflammation status in burn patients receiving PIR versus baseline.
• To assess the safety and impact of PIR on hemostasis.

Main Methods:

• Prospective enrollment of burn patients treated with PIR.
• Analysis of whole blood samples using thromboelastography and rotational thromboelastometry at four time points.
• Statistical analysis using mixed-effect models and Tukey's post hoc test.

Main Results:

• 35 patients analyzed; high prevalence of male patients, inhalation injury, and large burn sizes.
• No transfusion reactions or thrombotic events observed.
• No significant differences in coagulation parameters or fibrinolytic phenotypes were found with PIR compared to baseline.

Conclusions:

• Plasma-inclusive resuscitation (PIR) in burn patients was not associated with prothrombotic or lytic changes.
• Findings suggest PIR may be a safe adjunctive therapy in burn resuscitation.
• Further research is required to confirm efficacy and long-term outcomes of PIR.