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Updated: Jun 11, 2025
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
880
Dynamic death decisions: How mitochondrial dynamics shape cellular commitment to apoptosis and ferroptosis
Jesminara Khatun1, Jesse D Gelles1, Jerry Edward Chipuk2
1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Developmental Cell
|October 8, 2024
Summary
Mitochondria
Area of Science:
- Cell Biology
- Biochemistry
- Genetics
Background:
- Mitochondria are crucial for eukaryotic cell function and development.
- Mitochondrial dynamics maintain organelle health and diverse biochemistry.
- Mitochondria interact with regulated cell death (RCD) pathways.
Purpose of the Study:
- To review the role of mitochondrial dynamics in apoptosis and ferroptosis.
- To highlight how mitochondrial processes influence cell death decisions.
- To explore the link between organelle biochemistry and RCD.
Main Methods:
- Literature review of apoptosis and ferroptosis.
- Analysis of proteins and processes in mitochondrial dynamics.
- Examination of signaling pathways in RCD.
Main Results:
- Mitochondrial dynamics maintain distinct cellular compartments for RCD.
- Mitochondrial biochemistry is central to both apoptosis and ferroptosis.
- Mitochondrial proteins and processes regulate cell death signaling.
Conclusions:
- Mitochondrial dynamics are key regulators of apoptosis and ferroptosis.
- Organelle biochemistry and dynamics control cell fate.
- Mitochondria integrate diverse RCD pathways.
Keywords:
apoptosiscell biologycell deathferroptosismembranesmitochondriamitochondrial dynamicssignal transductionMore Related Videos
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