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Related Experiment Video

Updated: Jun 11, 2025

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
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Bariatric surgeries and cardiac structure and function: Systematic review and network meta-analysis.

Xiao-Qian Zhang1,2, Ke-Ning Chen3,4, Zu-Xuan Zhang1,2

  • 1Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|October 8, 2024
PubMed
Summary

Gastric bypass surgery significantly improves cardiac structure in obese patients, more so than other bariatric procedures. However, no bariatric surgery notably enhanced cardiac function (left ventricular ejection fraction).

Keywords:
bariatric surgeriescardiac functioncardiac structurenetwork meta‐analysis

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Area of Science:

  • Cardiology
  • Metabolic Surgery
  • Obesity Medicine

Background:

  • Obesity is a major risk factor for cardiovascular disease.
  • Bariatric surgery is an effective obesity treatment, but its cardiac effects vary.
  • Understanding the impact of different bariatric procedures on heart health is crucial.

Purpose of the Study:

  • To systematically review and perform a network meta-analysis on the effectiveness of bariatric surgeries on cardiac structure and function.
  • To compare the effects of various bariatric procedures against each other and non-surgical interventions.

Main Methods:

  • A systematic search of PubMed, Web of Science, and EMBASE databases was conducted.
  • Included studies compared bariatric surgeries with controls or other surgical methods.
  • Outcomes assessed included changes in left ventricular mass (LVM), left ventricular mass index (LVMI), and left ventricular ejection fraction (LVEF).

Main Results:

  • Gastric bypass significantly reduced LVM and LVMI compared to other bariatric surgeries.
  • No significant improvements in left ventricular ejection fraction (LVEF) were observed across any bariatric surgery type.
  • Biliopancreatic diversion with duodenal switch resulted in the most substantial reduction in body mass index.

Conclusions:

  • Gastric bypass demonstrates superior effectiveness in improving cardiac structure among bariatric surgeries.
  • Current evidence does not support significant improvements in cardiac function (LVEF) with any bariatric surgery.
  • Further research is needed to elucidate the mechanisms behind these differential effects on cardiac structure and function.