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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
Published on: January 20, 2023
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Caspase-8 in inflammatory diseases: a potential therapeutic target
Wangzheqi Zhang1, Chenglong Zhu1, Yan Liao1
1Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Cellular & Molecular Biology Letters
|October 8, 2024
Summary
Caspase-8 regulates cell death, including apoptosis, pyroptosis, and necroptosis (PANoptosis). Its dysregulation is linked to inflammatory diseases, offering therapeutic targets.
Area of Science:
- Biochemistry
- Cell Biology
- Immunology
Background:
- Caspase-8 is a cysteine-aspartic protease crucial for extrinsic apoptosis.
- Emerging evidence links caspase-8 to pyroptosis, necroptosis, inflammasomes, and cytokine modulation.
- PANoptosis integrates pyroptosis, apoptosis, and necroptosis, reflecting complex cell death pathways.
Purpose of the Study:
- To explore the multifaceted role of caspase-8 in cell death.
- To investigate the association between caspase-8 and inflammatory diseases.
- To identify potential therapeutic strategies targeting caspase-8.
Main Methods:
- Literature review of caspase-8 functions.
- Analysis of caspase-8's involvement in various cell death pathways.
- Examination of caspase-8's role in immune disorders, NDDs, sepsis, and cancer.
Main Results:
- Caspase-8 is a key regulator of cell survival and death.
- Caspase-8 activity influences PANoptosis.
- Aberrant caspase-8 expression correlates with inflammatory disease development.
Conclusions:
- Caspase-8 is central to diverse cell death mechanisms.
- Targeting caspase-8 offers potential therapeutic avenues for inflammatory conditions.
- Further research into caspase-8's role can advance treatment strategies.
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