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  1. Home
  3. Evaluation Of Urinary Podocin And Nephrin As Markers Of Podocyturia In Dogs With Leishmaniosis.
  1. Home
  3. Evaluation Of Urinary Podocin And Nephrin As Markers Of Podocyturia In Dogs With Leishmaniosis.

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Evaluation of urinary podocin and nephrin as markers of podocyturia in dogs with leishmaniosis.

Valeria Pantaleo1,2, Tommaso Furlanello1, Erika Carli1

  • 1San Marco Veterinary Clinic and Laboratory, Veggiano, Padua, Italy.

Parasites & Vectors
|October 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Urinary podocin and nephrin levels are lower in dogs with advanced leishmaniosis, indicating kidney damage. These markers help detect early renal injury in canine leishmaniosis.

Keywords:
Leishmania infantumCanineGlomerular diseaseRenal markers

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Area of Science:

  • Veterinary Medicine
  • Nephrology
  • Infectious Diseases

Background:

  • Renal disease is a primary cause of mortality in canine leishmaniosis.
  • Early detection of glomerular injury is crucial for preventing chronic kidney disease.
  • Podocyturia, indicated by urinary podocin and nephrin, can signal renal damage.

Purpose of the Study:

  • To assess urinary podocin and nephrin concentrations in dogs with leishmaniosis.
  • To evaluate these proteins as potential biomarkers for podocyturia and renal injury.
  • To correlate marker levels with the International Renal Interest Society (IRIS) staging of the disease.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure urinary podocin and nephrin.
  • Concentrations were normalized to urinary creatinine (uPoC and uNeC).
  • Dogs were categorized into healthy and leishmaniosis groups, with the latter staged using IRIS criteria.

    • Main Results:

    • Dogs with leishmaniosis exhibited lower urinary podocin and nephrin concentrations compared to healthy controls.
    • Healthy dogs and those in IRIS stage I had higher concentrations than dogs in advanced IRIS stages (II-IV).
    • No significant differences in uPoC and uNeC were found between healthy dogs and those with leishmaniosis across different IRIS stages.

    Conclusions:

    • Lower urinary podocin and nephrin concentrations correlate with more severe kidney disease in advanced IRIS stages of canine leishmaniosis.
    • Urinary nephrin was detected in healthy dogs, suggesting its potential as a novel biomarker.
    • These findings highlight the utility of urinary podocin and nephrin in assessing renal health in dogs affected by leishmaniosis.