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Parietal memory network and memory encoding versus retrieval impairments in PD-MCI patients: A hippocampal volume and

Serhat Sahin1, Halil Aziz Velioglu1,2, Burak Yulug3

  • 1Functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN), Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey.

CNS Neuroscience & Therapeutics
|October 9, 2024
PubMed
Abstract

Insights

Memory loss in Parkinson's Disease Mild Cognitive Impairment (PD-MCI) involves distinct brain atrophy patterns. Encoding failure shows hippocampal atrophy, while both failure types impact the lateral occipital cortex, suggesting Parietal Memory Network involvement.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Parkinson's Disease Mild Cognitive Impairment (PD-MCI) is associated with memory deficits.
  • The underlying pathophysiology of memory impairment in PD-MCI, specifically distinguishing between encoding and retrieval failures, remains unclear.

Purpose of the Study:

  • To investigate distinct hippocampal and cortical atrophy patterns in PD-MCI patients.
  • To differentiate these patterns based on memory impairment types: Retrieval Failure (RF) and Encoding Failure (EF).

Main Methods:

  • Included 16 healthy controls (HC) and 34 PD-MCI patients (18 RF, 16 EF).
  • Classified PD-MCI subtypes using the Verbal Memory Processes Test (VMPT).
  • Assessed hippocampal subfield volumes and cortical thicknesses via FreeSurfer software.

Main Results:

  • The EF group showed atrophy in left lateral occipital and right frontal/temporal regions compared to HC.
  • The RF group exhibited atrophy in left occipital/temporal/precentral and right frontal regions.
  • Significant hippocampal subfield atrophy (CA1, CA3, CA4) was observed in the EF group, but not between HC and RF groups.

Conclusions:

  • Gray matter atrophy patterns differ significantly between encoding and retrieval memory impairments in PD-MCI.
  • Hippocampal atrophy in the EF group suggests its role in memory decline and disease progression.
  • Shared atrophy in the lateral occipital cortex for both RF and EF groups indicates Parietal Memory Network involvement in PD-related memory issues.
Keywords:
Parkinson's disease‐mild cognitive impairmentcortical thicknessencoding failuregray matter volumehippocampusparietal memory networkretrieval failure

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