Related Experiment Video
Updated: Jun 11, 2025
05:52
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
14.9K
Risk Factors for Late-Onset Psychosis: A Case-Control Study
Joseph P Skinner1,2, Ann K Shinn1,3, Lauren V Moran1,2,3
1Division of Psychotic Disorders, McLean Hospital, Belmont, MA, USA.
Schizophrenia Bulletin
|October 9, 2024
Summary
Late-onset psychosis (LOP) risk factors include immigration, depression, anxiety, substance use, trauma, and caregiver burden. These life stressors and psychiatric conditions may contribute to LOP development.
Area of Science:
- Psychiatry
- Neuroscience
- Epidemiology
Background:
- Schizophrenia onset after age 40 affects up to 20% of cases.
- Late-onset psychosis (LOP) presents unique diagnostic and etiological challenges.
- Understanding LOP risk factors is crucial for early intervention and prevention.
Purpose of the Study:
- To identify risk factors associated with first-episode psychosis after age 40.
- To compare individuals with LOP to age-matched healthy controls.
- To elucidate the contributing factors to the development of LOP.
Main Methods:
- Case-control study utilizing electronic health records.
- Included 142 individuals aged 40-65 with first-episode psychosis (2013-2021).
- Matched 4 controls (N=568) per case on demographics and encounter year; analyzed risk factors via logistic regression.
Main Results:
- Immigration (OR 3.30), depression (OR 3.58), anxiety (OR 2.12), cannabis use (OR 3.00), alcohol use disorder (OR 5.46), polysubstance use (OR 4.22), severe trauma (OR 2.29), and caregiver burden (OR 15.26) significantly increased LOP odds.
- These associations remained significant after adjusting for all variables.
Conclusions:
- Life stressors, substance use, and psychiatric comorbidities are associated with LOP risk.
- Further research and independent prospective studies are needed to confirm these findings.
- Identifying causal pathways for LOP is essential for targeted interventions.
Related Concept Videos
01:29Psychological and Sociocultural Causes of Schizophrenia
80
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
80
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
489
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
489
01:29Biological Causes of Schizophrenia
46
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
46
01:17Schizophrenia
70
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
70
01:22Personality Disorders: Paranoid and Schizoid
31
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Paranoid Personality Disorder
Paranoid personality disorder is...
31
01:28Conduct Disorder
28
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
28