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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Heritability01:06

Heritability

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Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
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Polygenic Traits01:18

Polygenic Traits

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Related Experiment Video

Updated: Jun 11, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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GWAShug: a comprehensive platform for decoding the shared genetic basis between complex traits based on summary

Chen Cao1, Min Tian1, Zhenghui Li1

  • 1Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Nucleic Acids Research
|October 9, 2024
PubMed
Summary
This summary is machine-generated.

GWAShug provides a comprehensive resource for exploring the shared genetic basis of complex traits using accessible summary statistics. This platform simplifies genetic analysis with standardized methods and interactive tools for researchers.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Complex Traits

Background:

  • Understanding the shared genetic basis of complex traits is crucial for etiology, diagnosis, and therapy.
  • Existing resources lack comprehensive, accessible summary statistics for analyzing shared genetic architecture.
  • Analyzing shared genetic basis is challenging due to parameter selection and complex pipeline implementation.

Purpose of the Study:

  • To introduce GWAShug, a novel platform designed to address the limitations in analyzing shared genetic basis.
  • To provide a standardized, best-practice pipeline for genetic analysis of complex traits.
  • To create a comprehensive resource of high-quality GWAS summary statistics.

Main Methods:

  • Developed GWAShug with a standardized pipeline incorporating four trait-level and three molecular-level methods.
  • Included 539 high-quality GWAS summary statistics for European and East Asian populations after stringent quality control.
  • Facilitated interactive visualization, analysis, and data download via FTP links.

Main Results:

  • The GWAShug resource contains extensive data on trait pairs, including 54,945 measurement-based vs. disease-based and 43,902 disease-based vs. disease-based trait pairs.
  • Users can search for shared genetic basis information by trait name, MeSH term, and category.
  • An online analysis module allows users to analyze their own summary statistics with comprehensive outputs.

Conclusions:

  • GWAShug offers a valuable, user-friendly platform for exploring the shared genetic basis of complex traits.
  • The resource and analysis tools facilitate dynamic data exploration and personalized genetic research.
  • GWAShug is freely accessible, promoting wider research into genetic architectures of complex diseases.