Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cryoglobulinemia and fibronectin.

M Villar, F García-Bragado, J Joven

    Acta Haematologica
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Update on the usefulness of optical coherence tomography-mediated angiography in neurodegenerative diseases.

    Archivos de la Sociedad Espanola de Oftalmologia·2025
    Same author

    Influence of sex on chronic steroid-induced glaucoma: 24-Weeks follow-up study in rats.

    Experimental eye research·2023
    Same author

    Treatment of COVID-19 pneumonia with low-dose radiotherapy plus standard of care versus standard of care alone in frail patients : The SEOR-GICOR IPACOVID comparative cohort trial.

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2023
    Same author

    Deactivating environmental strains of <i>Escherichia coli</i>, <i>Enterococcus faecalis</i> and <i>Clostridium perfringens</i> from a real wastewater effluent using UV-LEDs.

    Heliyon·2023
    Same author

    Profile changes in admissions to a psychiatric hospitalisation unit over 15 years (2006-2021), considering the impact of the pandemic caused by SARS-CoV-2.

    Psychiatry research·2022
    Same author

    Performance of the SolWat system operating in static mode vs. dynamic for wastewater treatment: Power generation and obtaining reclaimed water.

    Journal of environmental management·2022
    Same journal

    Dapagliflozin in Patients with homozygous β-Thalassemia and Albuminuria.

    Acta haematologica·2026
    Same journal

    Efficacy of second-generation FLT3 inhibitors in FLT3-mutated AML: A meta-analysis of randomized controlled trials.

    Acta haematologica·2026
    Same journal

    Limited prognostic value of ELN classification and relevance of molecular ontogeny in acute myeloid leukemia post myeloproliferative neoplasms: a retrospective multicenter study.

    Acta haematologica·2026
    Same journal

    Real-World Data on First Relapse in Multiple Myeloma: Treatment Patterns and Outcomes in Finland Using Automated Data Collection.

    Acta haematologica·2026
    Same journal

    Comparative efficacy of donor lymphocyte infusions in augmenting graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation for patients with myeloid malignancies.

    Acta haematologica·2026
    Same journal

    COVID-19 infection in patients with follicular lymphoma and related indolent B-cell lymphomas receiving anti-CD20 monoclonal antibody maintenance therapy.

    Acta haematologica·2026
    See all related articles

    Fibronectin is consistently found in cryoprecipitates from patients with various diseases and cryoglobulin types. This study highlights fibronectin's constant presence in these immune complex formations.

    Area of Science:

    • Immunology
    • Protein Biochemistry

    Background:

    • Cryoglobulins are immunoglobulins that precipitate in the cold.
    • Their composition and clinical relevance vary widely among patients.
    • Fibronectin is a large glycoprotein involved in various biological processes.

    Purpose of the Study:

    • To investigate the presence of fibronectin in isolated and washed cryoglobulins.
    • To determine if fibronectin is a constant component across different cryoglobulin types and patient diseases.

    Main Methods:

    • Cryoglobulins were isolated from 30 patients with diverse diseases.
    • Immunoelectrophoresis was used to detect fibronectin in the cryoprecipitates.
    • Cryoglobulins were classified into types I, II, and III.

    Related Experiment Videos

    Main Results:

    • Fibronectin was detected in all cryoprecipitates, regardless of cryoglobulin type (I, II, or III).
    • This presence was confirmed even after extensive washing, indicating strong association.
    • The study included 2 type I, 3 type II, and 25 type III cryoglobulins.

    Conclusions:

    • Fibronectin is a constant component of cryoprecipitates in patients with different diseases and cryoglobulin types.
    • The findings suggest a significant role for fibronectin in immunoglobulin precipitation.
    • Further research is warranted to elucidate the specific mechanisms of fibronectin's involvement.