Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tamoxifen and oligospermia.

I Noci, E Chelo, O Saltarelli

    Archives of Andrology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patient-centered communication, patient satisfaction, and retention in care in assisted reproductive technology visits.

    Journal of assisted reproduction and genetics·2019
    Same author

    Doctor-couple communication during assisted reproductive technology visits.

    Human reproduction (Oxford, England)·2018
    Same author

    Comprehensive investigation in patients affected by sperm macrocephaly and globozoospermia.

    Andrology·2015
    Same author

    DNA methylation of HOXA10 in eutopic and ectopic endometrium.

    Human reproduction (Oxford, England)·2014
    Same author

    Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples.

    Andrology·2013
    Same author

    Expression of adhesion, attachment and invasion markers in eutopic and ectopic endometrium: a link to the aetiology of endometriosis.

    Human reproduction (Oxford, England)·2012

    Tamoxifen treatment improved sperm concentration and total sperm count in men with low sperm counts. However, it did not affect semen volume, sperm morphology, or motility.

    Area of Science:

    • Reproductive Endocrinology
    • Andrology
    • Pharmacology

    Background:

    • Oligospermia, characterized by low sperm count, is a significant cause of male infertility.
    • Normogonadotropic oligospermia presents a specific challenge where hormonal levels are within the normal range, yet sperm production is insufficient.

    Purpose of the Study:

    • To investigate the efficacy of Tamoxifen in improving seminal parameters in normogonadotropic oligospermic males.
    • To assess the hormonal effects of Tamoxifen treatment in this patient group.

    Main Methods:

    • A cohort of 30 normogonadotropic oligospermic males received Tamoxifen (20 mg/day) for 4 months.
    • Seminal parameters (volume, concentration, morphology, motility) were evaluated pre- and post-treatment.
    • Hormonal profiles (gonadotropins, testosterone, estradiol, prolactin) were monitored in a subset of patients.

    Related Experiment Videos

    Main Results:

    • Tamoxifen administration led to a statistically significant increase in mean sperm concentration and total sperm count (p < 0.05).
    • No significant changes were observed in semen volume, sperm morphology, or sperm motility.
    • Hormonal analysis revealed increased gonadotropins (particularly LH) and 17 beta-estradiol (E2) levels, with minimal testosterone variation and a slight decrease in prolactin (PRL).

    Conclusions:

    • Tamoxifen can be an effective therapeutic option for improving sperm count in men with normogonadotropic oligospermia.
    • The observed hormonal shifts suggest Tamoxifen influences the hypothalamic-pituitary-gonadal axis, potentially mediating its positive effects on spermatogenesis.