Ventral Hernia Repair With a Hybrid Absorbable-permanent Preperitoneal Mesh

Area of Science:

• Surgical Innovation
• Biomaterials Science
• Hernia Surgery

Background:

• Ventral hernia repair often involves permanent mesh prosthetics.
• Challenges include mesh-related complications and hernia recurrence.
• New biomaterials aim to improve outcomes by combining different material properties.

Purpose of the Study:

• To evaluate the safety and clinical outcomes of the GORE SYNECOR Preperitoneal Biomaterial (PRE device) for ventral hernia repair.
• To assess device and procedure endpoints, as well as patient-reported outcomes.
• To determine the efficacy of this novel mesh in complex hernia cases.

Main Methods:

• Multicenter retrospective review of patients undergoing ventral hernia repair with the PRE device.
• Analysis of device/procedure endpoints and patient-reported outcomes.
• Minimum follow-up of 1 year post-enrollment.

Main Results:

• 148 patients included, with a mean age of 56 years; 66.2% had VHWG grade 2 classification.
• Robotic (53.4%) and open (41.9%) approaches were common, with all meshes placed extraperitoneally.
• Low rates of procedure-related adverse events (8.8%), surgical site infections (4.8%), and surgical site occurrences (3.4% at 12 months) were observed. No hernia recurrences were reported.

Conclusions:

• The PRE device, combining absorbable and permanent mesh features, is safe and effective for complex ventral hernia repair.
• Retromuscular placement demonstrated reduced wound complications and recurrence rates compared to single-material meshes.
• This biomaterial offers a promising solution for challenging hernia cases.