AGT, CYP11B2 & ADRB2 gene polymorphism & essential hypertension (HT): A meta-analysis

Area of Science:

• Genetics
• Cardiovascular Disease Epidemiology
• Pharmacogenetics

Background:

• Genetic association studies for hypertension (HT) show conflicting results across diverse populations.
• Previous meta-analyses often overlooked population genetic ancestry as a confounding factor.
• Candidate gene variants (AGT-rs699, CYP11B2-rs1799998, ADRB2-rs1042713, rs1042714) have been implicated in HT.

Purpose of the Study:

• To re-evaluate and consolidate findings on the association between selected genetic variants and hypertension.
• To account for population genetic ancestry by categorizing data based on ancestry and/or geographical populations.
• To provide updated insights into the genetic basis of hypertension across different ancestries.

Main Methods:

• Systematic literature search of PubMed, Cochrane, and World of Science databases.
• Categorization of retrieved studies based on known genetic and/or geographical ancestry.
• Meta-analysis of genotype and allele data for specific single nucleotide polymorphisms (SNPs) in relation to hypertension.

Main Results:

• AGT-rs699-G showed significant association with HT in Indians (allele and dominant mode).
• CYP11B2-rs1799998-G was significantly associated with HT in Europeans (allele, recessive, and dominant modes).
• ADRB2-rs1042713-G was significantly associated with HT in East Asians (allele and recessive modes).

Conclusions:

• Genotype and allele frequencies vary significantly across diverse populations, leading to differential genetic associations with hypertension.
• This meta-analysis highlights population-specific genetic associations for selected SNPs and hypertension.
• Findings offer essential insights for selecting appropriate pharmacogenetic markers for effective hypertension management in diverse ancestral populations.