The ASPECT hydrocephalus system: investigating clinical applicability and system utility

Area of Science:

• Neurology
• Medical Informatics
• Clinical Research

Background:

• Hydrocephalus diagnosis and management are complicated by patient heterogeneity.
• The ASPECT Hydrocephalus System was introduced in 2023 for comprehensive patient description.

Purpose of the Study:

• To evaluate the clinical applicability and utility of the ASPECT Hydrocephalus System.
• To compare the ASPECT system with the International Classification of Disease (ICD-10) for hydrocephalus patient characterization.

Main Methods:

• Two hundred hydrocephalus patients (pediatric and adult) at Copenhagen University Hospital were analyzed.
• Patient data were described using the ASPECT Hydrocephalus System based on the latest brain imaging.

Main Results:

• The International Classification of Disease (ICD-10) often resulted in multiple or unspecific codes.
• All ASPECT factors (Anatomy, Symptomatology, Previous interventions, Complications, Time of onset) were applicable, with Etiology unknown in 15%.
• ASPECT factor analysis revealed a disconnect between symptoms and neuro-radiological findings, such as ventriculomegaly.

Conclusions:

• The ASPECT Hydrocephalus System is robust and applicable to a diverse hydrocephalus patient population.
• ASPECT provides comprehensive characterization beyond ICD-10 limitations, potentially improving clinical decision-making and research.
• Further validation in prospective studies is recommended to confirm feasibility and utility.