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Related Experiment Video

Updated: Jun 11, 2025

Medium Preparation for the Cultivation of Microorganisms under Strictly Anaerobic/Anoxic Conditions
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[Volume therapy: which preparation for which situation?]

Timo Mayerhöfer1, Georg F Lehner1, Michael Joannidis2

  • 1Gemeinsame Einrichtung für Intensiv- und Notfallmedizin, Department für Innere Medizin, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|October 9, 2024
PubMed
Summary
This summary is machine-generated.

Balanced crystalloids (BC) are recommended over 0.9% sodium chloride for fluid therapy, particularly for patients at risk of kidney injury. Albumin and hydroxyethyl starch have limited or harmful applications in intensive care.

Keywords:
ColloidsCrystalloid solutions, balancedNormal saline solutionSepsisSerum albumin, human

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Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Fluid Physiology

Context:

  • Volume therapy is crucial in critical care, with crystalloids and colloids being primary fluid choices.
  • 0.9% sodium chloride and balanced crystalloids (BC) are common crystalloid solutions.
  • Colloids include artificial options and human albumin.

Purpose:

  • To evaluate the comparative efficacy and safety of different fluid therapies in volume resuscitation.
  • To provide evidence-based recommendations for fluid selection in intensive care settings.

Summary:

  • Large studies indicate balanced crystalloids (BC) offer renal benefits over 0.9% sodium chloride, likely due to lower chloride content.
  • While some trials show no mortality difference, meta-analyses favor BC, especially for patients with acute kidney injury risk, acidemia, or hyperchloremia.
  • Human albumin is recommended only for specific conditions, and hydroxyethyl starch is associated with harm in intensive care.

Impact:

  • Shifts clinical practice towards prioritizing balanced crystalloids for improved renal outcomes.
  • Reduces the use of potentially harmful fluid therapies like hydroxyethyl starch.
  • Informs guidelines for fluid management in critically ill patients, optimizing patient safety and treatment efficacy.