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Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study.
Seth D Crockett1, Aasma Shaukat2, Olivia Delau2
1Division of Gastroenterology and Hepatology, Oregon Health & Science University and Portland VA Medical Center, Portland, Oregon, USA.
The American Journal of Gastroenterology
|October 9, 2024
Summary
White race, current smoking, and obesity are significant risk factors for developing precancerous serrated polyps (SPs). Understanding these factors is crucial for early detection and prevention strategies.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Risk factors for serrated polyps (SPs) remain largely unknown.
- Serrated polyps are precursors to colorectal cancer, necessitating identification of associated risk factors.
Purpose of the Study:
- To investigate and identify demographic and lifestyle risk factors associated with serrated polyps.
- To determine the association between participant characteristics and the presence of sessile serrated lesions or traditional serrated adenomas.
Main Methods:
- Multivariable analyses were conducted on data from a multicenter colonoscopy study.
- Odds ratios were calculated to assess the risk of SPs based on participant characteristics.
Main Results:
- White race was significantly associated with a higher risk of SPs compared to Black race (aOR 4.64).
- Current smoking and obesity were also identified as risk factors for serrated polyps.
Conclusions:
- White race, current smoking, and obesity are confirmed risk factors for precancerous serrated polyps.
- These findings can inform targeted screening and prevention efforts for colorectal cancer.
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