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Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study
Seth D Crockett1, Aasma Shaukat2, Olivia Delau2
1Division of Gastroenterology and Hepatology, Oregon Health & Science University and Portland VA Medical Center, Portland, Oregon, USA.
Introduction:
Risk factors for serrated polyps (SPs) are not well understood.
Methods:
Multivariable analyses of data from a multicenter colonoscopy-based study estimated odds ratios for having either a sessile serrated lesion or traditional serrated adenoma according to participant characteristics.
Results:
Six thousand seventy-eighty participants were included in the analyses (565 with either a sessile serrated lesion or traditional serrated adenoma). White race was associated with a higher risk of SPs compared with Black race (adjusted odds ratio 4.64, 95% confidence interval 1.89-11.41). Obesity and current smoking were also associated with a higher risk of SPs.
Discussion:
White race, smoking, and obesity are risk factors for precancerous SPs.
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