Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cerebrospinal fluid vasopressin--changes in depression.

A Gjerris, M Hammer, P Vendsborg

The British Journal of Psychiatry : the Journal of Mental Science

|December 1, 1985

Summary

Cerebrospinal fluid (CSF) vasopressin (AVP) levels were lower in depressed patients. No differences in CSF thyrotropin-releasing hormone (TRH) were observed across psychiatric diagnoses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inverted V-shaped extracapsular stabilisation technique and arthroscopic findings in six dogs with medial shoulder instability.

The Journal of small animal practice·2021

Same author

Comparison of algorithms to suppress artifacts from the natural lens in fluorescence lifetime imaging ophthalmoscopy (FLIO).

Biomedical optics express·2020

Same author

Glycemic variability in patients with gastrointestinal cancer: An integrative review.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2020

Same author

A comparison of postoperative respiratory complications associated with the use of desflurane and sevoflurane: a single-centre cohort study.

Anaesthesia·2020

Same author

[Sonography of the foot in rheumatology : Ultrasound diagnostics of the ankle joint and foot in the rheumatological routine].

Zeitschrift fur Rheumatologie·2020

Same author

The flicker response of venous oxygen saturation is significantly reduced in the early and late stages of age-related macular degeneration.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2019

Area of Science:

Neuroendocrinology
Psychiatry
Clinical Chemistry

Background:

Investigating neuropeptide and neurotransmitter levels in cerebrospinal fluid (CSF) and plasma is crucial for understanding psychiatric disorders.
Thyrotropin-releasing hormone (TRH), vasopressin (AVP), adrenaline (A), and noradrenaline (NA) are key neurochemicals implicated in mood regulation and stress response.

Purpose of the Study:

To compare CSF and plasma levels of TRH, AVP, A, NA, and osmolality in psychiatric patients (depression, mania, schizophrenia) and healthy controls.
To explore correlations between these neurochemical markers and disease severity or diagnostic groups.

Main Methods:

Measurement of CSF and plasma biomarkers including TRH, AVP, A, NA, and osmolality.
Patient classification using ICD-9 criteria and diagnostic subgroups (endogenous/non-endogenous depression, mania, schizophrenia).

Related Experiment Videos

Assessment of depressive symptom severity using the Newcastle Rating Scale, BRMES, BRMS, and BPRS.

Main Results:

Significantly lower CSF-AVP concentrations were found in both endogenous and non-endogenous depression groups compared to controls.
No significant differences in CSF-TRH levels were observed among the diagnostic groups and controls.
A positive correlation was identified between CSF-TRH and CSF-A levels.

Conclusions:

Reduced CSF-AVP may be a biomarker for depressive disorders.
CSF-TRH levels do not appear to differentiate between major psychiatric diagnoses in this cohort.
The relationship between CSF-TRH and CSF-A warrants further investigation in psychiatric research.