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Amyloid Fibrils

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

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Related Experiment Video

Updated: Jun 11, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

[Amyloidosis - The pathologist's perspective].

¹Service d'anatomie et cytologie pathologiques, hôpital Tenon, Paris Sorbonne université, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75970 Paris, France.

Annales De Pathologie

|October 9, 2024

Summary

This summary is machine-generated.

Pathologists are crucial for diagnosing and typing amyloidosis, even with new imaging techniques. Familiarity with Congo red staining and immunohistochemistry pitfalls is essential for accurate diagnosis.

Keywords:

Amyloidosis Amylose Congo Red Immunohistochemistry Immunohistochimie Rouge Congo

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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease

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Published on: April 19, 2021

Area of Science:

Pathology
Medical Diagnostics
Histopathology

Context:

Transthyretin amyloidosis diagnosis is evolving with scintigraphy.
Pathological diagnosis remains essential for definitive amyloidosis typing.
Challenges exist in histological interpretation and immunohistochemistry.

Purpose:

To highlight the central role of pathologists in amyloidosis diagnosis and subtyping.
To identify common pitfalls in anatomo-pathological diagnosis of amyloidosis.
To recommend expert center consultation for complex cases.

Summary:

Pathological assessment is vital for amyloidosis diagnosis and typing, complementing scintigraphy.
Known pitfalls in Congo red staining and immunohistochemistry can hinder accurate diagnosis.
Expert centers are recommended for challenging cases or when typing is uncertain.

Impact:

Improved diagnostic accuracy for amyloidosis.
Enhanced understanding of histological diagnostic challenges.
Guidance on utilizing expert centers for complex amyloidosis cases.