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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
126
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
118
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

147
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
147
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

126
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
126
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

143
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
143

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Related Experiment Video

Updated: Jun 11, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Ulcerative colitis: molecular insights and intervention therapy.

Yuqing Liang1,2, Yang Li3, Chehao Lee4

  • 1School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Molecular Biomedicine
|October 9, 2024
PubMed
Summary

Ulcerative colitis (UC) treatments are limited, with only 40% achieving remission. New research explores biologics, gut microbiota therapies like fecal microbiota transplantation (FMT), and herbal remedies for improved ulcerative colitis management.

Keywords:
Alteration of intestinal floraBiologic therapyGenetic predispositionHerbal treatmentImmune dysregulationUlcerative colitis (UC)

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting millions globally.
  • Current UC treatments, including 5-ASA, corticosteroids, immunosuppressants, and biologics, show limited efficacy, with a one-year remission rate around 40%.

Purpose of the Study:

  • To review recent findings on UC pathogenesis, including genetic, immune, and microbiota factors.
  • To discuss emerging and current therapeutic strategies for UC management.

Main Methods:

  • Review of current literature on ulcerative colitis mechanisms.
  • Analysis of biologic therapies, herbal medicine, microecologics, and fecal microbiota transplantation (FMT).

Main Results:

  • UC pathogenesis involves genetic susceptibility, immune dysregulation, and gut microbiota alterations.
  • Biologics, microecologics (probiotics, prebiotics), FMT, and herbal therapies show promise for UC treatment.

Conclusions:

  • Novel therapeutic approaches are needed to improve clinical remission rates in UC.
  • Targeting gut microbiota and exploring complementary therapies represent promising avenues for UC management.