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Investigating the causal relationship between inflammatory bowel disease and simple appendicitis using Mendelian
Yawei Zhang1, Lichao Yang2, Lianwen Yuan3
1Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Scientific Reports
|October 9, 2024
Summary
Inflammatory bowel disease (IBD) may reduce the risk of simple appendicitis, according to a genetic study. However, simple appendicitis does not appear to affect IBD risk. This research used Mendelian randomization to explore the causal link.
Area of Science:
- Genetics
- Gastroenterology
- Epidemiology
Background:
- The etiological relationship between simple appendicitis and inflammatory bowel disease (IBD) remains unclear.
- Investigating potential causal links is crucial for understanding disease pathogenesis and developing targeted interventions.
Purpose of the Study:
- To explore the potential causal relationship between simple appendicitis and IBD using a genetic approach.
- To determine the directionality of the potential causal effect between these conditions.
Main Methods:
- Utilized Mendelian randomization (MR) analysis with genome-wide association study (GWAS) data from European ancestry populations.
- Employed the Inverse Variance Weighting (IVW) method for bidirectional MR analysis.
- Analyzed data from large cohorts for IBD, Crohn's disease (CD), ulcerative colitis (UC), and simple appendicitis.
Main Results:
- IBD was associated with a reduced risk of simple appendicitis (OR: 0.947, p=0.005), with similar findings for CD and UC.
- Reverse MR analysis indicated no significant causal relationship between simple appendicitis and the risk of developing IBD, CD, or UC.
- The results suggest a potential negative causal effect of IBD on simple appendicitis occurrence.
Conclusions:
- IBD may have a protective effect against the development of simple appendicitis.
- Simple appendicitis does not appear to causally influence the risk of developing IBD.
- Genetic evidence supports a one-way causal relationship from IBD to simple appendicitis.
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