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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Nutrition And Dietetics
  9. Food Properties (incl. Characteristics And Health Benefits)
  11. Dietary Restriction Impacts Health And Lifespan Of Genetically Diverse Mice

Dietary restriction impacts health and lifespan of genetically diverse mice

Andrea Di Francesco1, Andrew G Deighan2, Lev Litichevskiy3,4

  • 1Calico Life Sciences LLC, South San Francisco, CA, USA. andrea@calicolabs.com.

Nature
|October 9, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Caloric restriction and intermittent fasting extended mouse lifespan, but health benefits varied. Genetics played a larger role than diet in longevity, and improved health did not always correlate with extended lifespan.

Area of Science:

  • Aging research
  • Longevity studies
  • Dietary interventions

Background:

  • Caloric restriction (CR) is known to extend lifespan in various species.
  • Intermittent fasting (IF) is a more sustainable dietary restriction for humans, but its efficacy is less understood.
  • Identifying optimal dietary restriction methods is crucial for developing human health and longevity interventions.

Purpose of the Study:

  • To assess the effects of graded caloric restriction (20%, 40%) and intermittent fasting (1-2 days/week) on mouse health and lifespan.
  • To explore the relationship between specific health traits, dietary interventions, and lifespan extension.
  • To determine if metabolic improvements from dietary restriction correlate with increased longevity.

Main Methods:

  • Utilized 960 genetically diverse female mice.

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  • Administered graded levels of caloric restriction and intermittent fasting.
  • Assessed lifespan, healthspan, body weight, immune cell populations, red blood cell distribution width, and adiposity.

    • Main Results:

    • Both CR and IF extended lifespan proportionally to the degree of restriction; genetics had a greater influence than diet.
    • 40% CR showed the most lifespan extension but caused lean mass loss and immune changes.
    • IF did not extend lifespan in mice with high baseline body weight and 2-day IF disrupted erythroid cells.
    • Metabolic improvements (reduced adiposity, lower glucose) did not correlate with lifespan extension.

    Conclusions:

    • Dietary restriction extends lifespan, but health improvements and lifespan extension are not always synonymous.
    • Genetics significantly influences lifespan, more so than dietary interventions.
    • Findings challenge the direct correlation between metabolic health markers and longevity, suggesting dietary restriction's effects extend beyond counteracting obesity.