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Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
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Effect Modification by Obesity on Nonsurgical Periodontal Treatment.

E Kaye1, R McDonough1, A Singhal2

  • 1Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

JDR Clinical and Translational Research
|October 10, 2024
PubMed
Summary

Obesity negatively impacts periodontal treatment success, reducing the likelihood of successful outcomes. Patients with obesity experienced less improvement in deep pocket reduction compared to healthy-weight individuals.

Keywords:
body mass indexdentalobeseperiodontal attachment lossperiodontal pocketretrospective studies

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Area of Science:

  • Periodontology
  • Public Health
  • Obesity Research

Background:

  • Obesity is linked to higher rates of periodontal disease.
  • Understanding the impact of body mass index (BMI) on periodontal treatment is crucial for effective patient management.

Purpose of the Study:

  • To investigate if body mass index (BMI) modifies the outcomes of nonsurgical periodontal treatment.
  • To compare periodontal treatment success rates between obese, overweight, and healthy-weight patients.

Main Methods:

  • Retrospective cohort study of 344 patients with periodontal disease treated at a dental school clinic.
  • Patients categorized by BMI: obese (≥30 kg/m²), overweight (25-29.9 kg/m²), and healthy (18-24.9 kg/m²).
  • Treatment success defined as absence of pockets ≥5 mm; analyzed using generalized linear models, adjusting for covariates.

Main Results:

  • Obesity was associated with a significantly lower likelihood of successful nonsurgical periodontal treatment (OR=0.47).
  • Overweight individuals did not show a significant difference in treatment success compared to healthy-weight patients.
  • Greater reductions in sites with deep pockets (PD ≥5 mm) and clinical attachment loss (CAL ≥5 mm) were observed in healthy-weight patients post-treatment.

Conclusions:

  • Obesity adversely affects the effectiveness of nonsurgical periodontal therapy.
  • Findings suggest BMI is an important factor influencing periodontal treatment outcomes in a clinical setting.