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TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the

Lichan Chen1, Nansong Xu2, DongMei Gou3

  • 1Department of Laboratory Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital; Shenzhen Key Laboratory of Medical Laboratory and Molecular Diagnostics; Guangzhou Medical University, Shenzhen, China.

Cancer Medicine
|October 10, 2024
PubMed
Summary

TRPM8 (Transient Receptor Potential Melastatin 8) acts as a tumor suppressor in hepatocellular carcinoma (HCC). Decreased TRPM8 expression correlates with poor prognosis, and its upregulation inhibits HCC progression via the RTP3/STAT3 pathway.

Keywords:
AD80RTP3/STAT3 pathwayTRPM8hepatocellular carcinoma

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