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Precision Medicine in Periodontics: A Literature Review
Mrunalini Gundelly1, Santosh V Pusuluri1, Rekha R Koduganti1
1Periodontics, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
Cureus
|October 10, 2024
Summary
Precision periodontics uses biomarkers for patient-centered treatment of periodontitis. Validated diagnostic biomarkers are needed to advance personalized periodontal care and improve patient outcomes.
Area of Science:
- Periodontology
- Biomarker Discovery
- Genomics
Background:
- Periodontitis is a prevalent inflammatory disease with significant systemic health implications.
- Current diagnostic methods (pocket depth, attachment loss, bone loss) have limitations in guiding precise therapy.
- The need for advanced, patient-centered approaches in periodontitis management is critical.
Purpose of the Study:
- To explore the foundations of personalized therapy in periodontal diagnosis.
- To discuss the current status and future potential of periodontal biomarkers.
- To highlight the role of biomarkers in advancing precision periodontics.
Main Methods:
- Review of current diagnostic methods in periodontitis.
- Exploration of precision periodontics principles (genomics, bioinformatics, biomarkers).
- Analysis of the role and validation of biomarkers in periodontal diagnosis.
Main Results:
- Traditional periodontal diagnostics are insufficient for complex disease management.
- Precision periodontics integrates advanced technologies for tailored patient treatment.
- A significant gap exists in validated periodontal biomarkers for clinical diagnostic use.
Conclusions:
- Validated periodontal biomarkers are essential for implementing precision periodontics.
- Personalized therapy holds promise for more effective periodontitis prevention and management.
- Further research into biomarker discovery and validation is crucial for advancing periodontal practice.
