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Related Experiment Video

Updated: Jun 11, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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The Strong Correlation Between Multiple Births and Preterm Birth Rates in Greece From 1991 to 2022.

Nikolaos Vlachadis1, Dionysios N Vrachnis2, Nikolaos Loukas3

  • 1Department of Obstetrics and Gynecology, General Hospital of Messinia, Kalamata, GRC.

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|October 10, 2024
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Summary
This summary is machine-generated.

The study found a strong link between rising multiple births and preterm births in Greece from 1991-2022. Multiple pregnancies significantly contributed to the increase in preterm birth rates, highlighting a key public health concern.

Keywords:
greecemultiple birthsnational trendpreterm birthpreterm birth rate

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Area of Science:

  • Reproductive Health
  • Perinatology
  • Public Health Statistics

Background:

  • Preterm birth rate (PBR) in Greece has risen between 1991 and 2022.
  • Multiple births are a known risk factor for preterm birth.

Purpose of the Study:

  • To investigate the correlation between the rising preterm birth rate (PBR) and the incidence of multiple births in Greece from 1991 to 2022.
  • To quantify the impact of multiple pregnancies on preterm birth trends.

Main Methods:

  • Utilized official live birth data from the Hellenic Statistical Authority (1991-2022).
  • Calculated PBR (<37 weeks) and multiple birth rate (MBR) per 100 live births.
  • Employed Spearman's rank correlation and linear regression models to assess the association.

Main Results:

  • A very strong positive correlation (Spearman's rho = 0.950, p < 0.001) was observed between PBR and MBR.
  • Linear regression indicated MBR explained 83.8% (R-squared = 0.838) of the rise in PBR.
  • The correlation was strongest for moderate and late preterm births and particularly high during 1991-2011.

Conclusions:

  • A significant positive association exists between multiple birth rates and preterm birth rates in Greece.
  • Multiple pregnancies are a major driver of the observed increase in preterm births.
  • The findings underscore the need for targeted interventions for multiple pregnancies to reduce prematurity.