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Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths

  • 0Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.
Oncology Letters +

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October 10, 2024

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October 10, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Postoperative infectious complications (ICs) after gastrectomy may increase non-gastric cancer-related deaths (NGCDs). Patients with ICs showed worse survival, suggesting ICs contribute to mortality beyond their direct impact.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Infectious Diseases

Background

  • Infectious complications (ICs) are significant causes of postoperative mortality in cancer patients.
  • The specific impact of ICs following gastrectomy on non-gastric cancer-related deaths (NGCDs) is not well understood.

Purpose Of The Study

  • To investigate the influence of postoperative infectious complications (ICs) after gastrectomy on non-gastric cancer-related deaths (NGCDs).

Main Methods

  • Retrospective analysis of 712 patients undergoing curative gastrectomy for gastric cancer.
  • Categorization into infectious complication (IC) and non-IC groups.
  • Comparison of clinicopathological factors and non-gastric cancer-related survival (NGCS) rates.
  • Multivariate analysis for NGCD risk factors in a background factor-adjusted cohort.

Main Results

  • 112 out of 712 patients developed infectious complications (Clavien-Dindo grade ≥II).
  • The IC group had a significantly higher 5-year cumulative incidence of NGCD (17.8%) compared to the non-IC group (10.6%; P=0.021).
  • Multivariate analysis identified older age, low prognostic nutritional index, low skeletal muscle index, and high Charlson comorbidity index (≥1) as risk factors for NGCD, independent of ICs.

Conclusions

  • Infectious complications after gastrectomy are associated with worse non-gastric cancer-related survival.
  • The IC group presented with more pre-existing risk factors for NGCD, indicating a potential multifactorial contribution to increased mortality.

Keywords:

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