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Rabies virus as vector for development of vaccine: pros and cons

Yan Li1,2, Houcheng Zhou1, Qian Li3

  • 1College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.

Frontiers in Veterinary Science
|October 10, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
inactivated RV-vectored vaccinelive-attenuated RV-vectored vaccinerabies virusreplication-deficient RV-vectored vaccinereverse genetics

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Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...