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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Current Knowledge on Nail Involvement in Autoimmune Bullous Disorders.

Laura Vollono1, Matilde Iorizzo2, Bertrand Richert3

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Nail unit involvement in autoimmune bullous disorders often lacks blisters, presenting as paronychia or onycholysis. Early recognition of these nail changes is crucial for timely diagnosis and management of these conditions.

Keywords:
Autoimmune bullous diseasesBlistering disordersBullous lupus erythematosusBullous pemphigoidEpidermolysis bullosa acquisitaLinear IgA diseaseNail disordersNail dystrophyPemphigus

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Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Limited research exists on nail unit involvement in autoimmune bullous disorders, primarily in case reports.
  • Nail manifestations are common yet often overlooked, differing from typical skin blistering.

Purpose of the Study:

  • To highlight the clinical significance of nail unit involvement in autoimmune bullous disorders.
  • To discuss the diagnostic challenges and immunological aspects of nail involvement.
  • To emphasize the correlation between nail changes and disease severity.

Main Methods:

  • Review of existing literature on autoimmune bullous disorders and nail unit manifestations.
  • Analysis of clinical presentations, diagnostic methods (histopathology, immunofluorescence), and immunological features.
  • Correlation of nail involvement with specific autoimmune bullous diseases.

Main Results:

  • Nail involvement presents with diverse alterations like paronychia, onychomadesis, and onycholysis, rarely with blisters.
  • Autoimmune bullous disorders such as pemphigus vulgaris, bullous pemphigoid, and others can affect the nail unit.
  • Diagnosis relies on histopathological and immunofluorescence findings, and nail changes can indicate disease severity.

Conclusions:

  • Nail involvement in autoimmune bullous disorders is a significant clinical sign, often presenting without blisters.
  • Atypical paronychia should prompt consideration of autoimmune bullous disorders.
  • Further research is needed to establish specific therapeutic strategies for nail involvement.