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Updated: Jun 11, 2025

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample
Weige Li1, Qian Wang1, Wenjie Li1
1Graduate School, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Objective:
The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis.
Methods:
The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension.
Results:
A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044-1.071; P < 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032-1.07; P < 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome.
Conclusion:
There is a positive causal relationship between GERD and hypertension.
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