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Oocyte and embryo donation in IVF programmes.

P J Lütjen, J F Leeton, J K Findlay

Clinics in Obstetrics and Gynaecology

|December 1, 1985

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A new hormone therapy mimics a natural menstrual cycle, enabling pregnancy in women with ovarian failure. This cyclic steroid regimen supports early pregnancy via in vitro fertilization and embryo transfer.

Area of Science:

Reproductive Endocrinology
Obstetrics and Gynecology

Background:

Ovarian failure and agenesis present significant challenges for conception.
Physiological hormone replacement is crucial for successful pregnancy in assisted reproductive technologies.

Purpose of the Study:

To describe a novel cyclic steroid replacement regimen for oestradiol and progesterone.
To assess the regimen's efficacy in achieving a secretory endometrium and supporting pregnancy.

Main Methods:

Administered a cyclic regimen of oestradiol and progesterone to mimic a normal menstrual cycle.
Combined hormone therapy with in vitro fertilization and embryo transfer (IVF-ET).
Monitored plasma steroid and human chorionic gonadotropin (hCG) levels for regimen adjustment.

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Main Results:

Achieved physiological plasma concentrations of oestradiol and progesterone.
Successfully stimulated a secretory endometrium, indicating treatment suitability.
Established pregnancy in three women with complete ovarian failure or agenesis using IVF-ET.

Conclusions:

The described cyclic steroid regimen effectively supports pregnancy in women with ovarian insufficiency.
This approach offers a viable pathway to pregnancy for patients with complete ovarian failure.
Further research into hormone action, pregnancy maintenance, and parturition is warranted.