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Mathilde Dupré1, Manon Marc1, Jean-François Bussières2
1, candidate au D. Pharm., est assistante de recherche à l'Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, Montréal (Québec).
Background:
The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.
Objective:
To evaluate the effectiveness of decontamination scenarios.
Methods:
This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm2).
Results:
Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (n = 18), 99.90% (SD 0.15%) after 2 cleanses (n = 18), and 99.95% (SD 0.06%) after 3 cleanses (n = 15).
Conclusion:
The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.