Palladium-catalyzed cross-coupling of arylcarboxylic acid 2-pyridyl esters with terminal alkynes
Hang Yu1, Jing-Jing Nie1, Zhong-Xia Wang1
1CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. zxwang@ustc.edu.cn.
Abstract:
In the presence of Na2CO3, the combination of PdCl2(dppf), dppp and CuI catalyzes the decarbonylative coupling of arylcarboxylic acid 2-pyridyl esters with terminal alkynes to afford 1,2-disubstituted acetylenes. (Hetero)aryl, alkyl, and silylacetylenes and various electron-donating and -withdrawing group-substituted arylcarboxylic acid 2-pyridyl esters can be used in this transformation, with a range of functional groups showing compatibility.
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