RETRACTED: SARS-CoV2 mRNA vaccine intravenous administration induces myocarditis in chronic inflammation

Area of Science:

• Immunology
• Cardiology
• Pharmacology

Background:

• COVID-19 messenger RNA (mRNA) vaccines were developed for pandemic conditions.
• Their effects on chronic inflammatory conditions and varying administration routes require investigation.

Purpose of the Study:

• To investigate the cardiac toxicity and immunogenicity of mRNA vaccines in a mouse model of chronic inflammation.
• To assess the impact of different injection routes on these effects.

Main Methods:

• Utilized a mouse model with induced chronic inflammation.
• Administered mRNA vaccines via intravenous (IV) and potentially other routes (route not specified for comparison).
• Assessed cardiac inflammation (pericarditis, myocarditis) and measured inflammatory cytokines (IL-1beta, IL-6) and serum troponin I (TnI).

Main Results:

• Intravenous mRNA vaccination exacerbated cardiac inflammation, including pericarditis and myocarditis, in both healthy and chronically inflamed mice.
• Immunization led to mild cardiac inflammation and increased IL-1beta and IL-6 levels.
• IV mRNA vaccination significantly increased serum troponin I in mice with lipopolysaccharide (LPS)-induced chronic inflammation, indicating cardiac damage.

Conclusions:

• Intravenous mRNA vaccine administration may increase cardiotoxicity in individuals with chronic inflammatory conditions.
• The injection route significantly influences the cardiac effects of mRNA vaccines.
• Further research is necessary to elucidate the mechanisms underlying these route-dependent cardiac effects.