Related Experiment Video
Updated: Jun 10, 2025
09:44
Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
2.1K
Avian pathogenic Escherichia coli (APEC): current insights and future challenges
Saqib Nawaz1, Zhihao Wang2, Yan Zhang2
1Engineering Research Center for the Prevention and Control of Animal Original Zoonosis, Fujian Province, College of Life Science, Longyan University, Longyan, 364012, Fujian, China; Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China.
Poultry Science
|October 10, 2024
Summary
Avian pathogenic Escherichia coli (APEC) is a growing foodborne threat. This review details APEC
Area of Science:
- Veterinary Microbiology
- Food Safety
- Zoonotic Diseases
Background:
- Avian pathogenic Escherichia coli (APEC) causes colibacillosis in poultry.
- APEC is increasingly recognized as a potential foodborne zoonotic pathogen.
- Understanding APEC pathogenesis is crucial for public health and animal welfare.
Purpose of the Study:
- To review APEC's virulence factors and pathogenesis.
- To assess the zoonotic potential of APEC.
- To update on antibiotic resistance, vaccine research, and alternative management strategies for APEC.
Main Methods:
- Comprehensive literature review of APEC research.
- Analysis of established and novel virulence factors.
- Evaluation of epidemiological data and antibiotic resistance patterns.
Main Results:
- APEC possesses diverse virulence factors, including TCS, adhesins, and toxins.
- Younger birds and stress factors increase APEC susceptibility and severity.
- APEC O145 is a prevalent serotype; APEC exhibits high-level antibiotic resistance, including to carbapenems.
Conclusions:
- APEC poses a significant zoonotic risk that should not be underestimated.
- A broad-spectrum APEC vaccine is urgently needed.
- Virulence inhibitors offer a promising alternative strategy to combat APEC infections and resistance.
Related Concept Videos
01:15Diversity of Protists I
1
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
1
01:27Diversity of Protists II
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...