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How Biologics Have Changed the Drug Discovery Landscape
1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA;
Annual Review of Pharmacology and Toxicology
|October 10, 2024
Summary
Biologic therapeutics, driven by advances in molecular biology and immunology, have transformed drug discovery and development. Future evolution includes mRNA therapeutics and AI applications.
Area of Science:
- Biotechnology
- Immunology
- Oncology
- Molecular Genetics
Background:
- Biologic therapeutics have rapidly advanced due to breakthroughs in molecular biology, genetics, immunology, and oncology.
- These advancements have significantly reshaped the entire drug discovery and development pipeline.
Purpose of the Study:
- To outline the impact of biologic therapeutics on the drug discovery and development process.
- To highlight the complexities and necessary adaptations in manufacturing, safety, and clinical testing for biologics.
- To project future trends including mRNA therapeutics and artificial intelligence.
Main Methods:
- Biologics are produced by living organisms.
- Screening libraries are generated via immunization or phage display.
- Lead optimization employs advanced protein engineering for enhanced drug properties and specificity.
Main Results:
- Manufacturing biologics is complex, requiring specialized facilities.
- Assessing pharmacology and safety presents challenges due to species specificity.
- Clinical testing requires a more cautious approach due to limited preclinical data predictability.
Conclusions:
- Biologic therapeutics have fundamentally altered drug discovery and development.
- The field is poised for further evolution with emerging technologies like mRNA therapeutics and AI.
Keywords:
advances in drug discoverybiologic therapeutics developmentdevelopment of biologicsdevelopment of biosimilarsdiscovery of biologic therapeuticsprotein engineering of biologicsMore Related Videos
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