Related Experiment Video For Lepidic
Updated: Aug 13, 2026
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
Prognostic Impact of Non-Predominant Lepidic Components in Pathologic Stage I Invasive Nonmucinous Adenocarcinoma
Joonseok Lee1, Jae Hyun Jeon1, Jin-Haeng Chung2
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Republic of Korea.
Introduction:
This study investigated the prognostic impact of non-predominant lepidic components in invasive nonmucinous adenocarcinoma.
Methods:
Patients who underwent lobectomy and were diagnosed with stage I nonmucinous, non-lepidic-predominant invasive adenocarcinoma based on pathologic findings were included. Tumors were staged according to the eighth edition of TNM classification and categorized on the basis of the presence of lepidic components in the final pathologic findings. Overall survival (OS) and recurrence-free survival (RFS) were analyzed before and after applying inverse probability of treatment weighting. Competing risk analyses for recurrence were also compared in the two groups.
Results:
Of the 1270 patients, 858 (67.6%) had lepidic components (+). The pathologic stage and histologic grade were higher in the lepidic (-) group (p < 0.001, respectively). The 5-year OS and RFS were significantly worse in the lepidic (-) group than in the lepidic (+) group (OS: 88.2% versus 94.9%, p < 0.001; RFS: 79.4% versus 91.9%, p < 0.001). These trends were consistent after weighted analysis (OS: 92.4% versus 96.4%, p = 0.029; RFS: 85.6% versus 92.3%, p = 0.007). The 5-year cumulative incidence of any recurrence was 14.0% in the lepidic (-) group and 4.1% in the lepidic (+) group (p < 0.001). Multivariable Fine-Gray regression analysis found that the lepidic (+) group exhibited a lower risk of recurrence than did the lepidic (-) group (hazard ratio = 0.52, 95% confidence interval: 0.29-0.93, p = 0.031).
Conclusions:
In pathologic stage I invasive nonmucinous adenocarcinoma, the presence of histologically diagnosed non-predominant lepidic components might be associated with a better prognosis after curative surgery.
