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Association between circulating inflammatory proteins and benign prostatic disease: a Mendelian randomization study.

Hongliang Cao1, Chengdong Shi1, Zulipikaer Aihemaiti2

  • 1Department of Urology, The First Hospital of Jilin University, Changchun, 130021, China.

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|October 10, 2024
PubMed
Summary

This study used Mendelian randomization to explore causal links between 91 inflammatory proteins and benign prostatic disease (BPD). Findings suggest certain protein levels may influence BPD risk and progression, offering potential diagnostic and therapeutic targets.

Keywords:
Benign prostatic diseaseCausal effectsCirculating inflammatory proteinsMendelian randomization

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Area of Science:

  • Genetics
  • Immunology
  • Urology

Background:

  • Circulating inflammatory proteins have been linked to benign prostatic disease (BPD).
  • A causal relationship between specific inflammatory proteins and BPD requires further investigation.

Purpose of the Study:

  • To investigate the causal associations between 91 circulating inflammatory proteins and benign prostatic disease (BPD) using Mendelian randomization.
  • To explore potential bidirectional relationships between inflammatory proteins and BPD subtypes like benign prostatic hyperplasia (BPH) and prostatitis.

Main Methods:

  • Utilized Mendelian randomization (MR) with genome-wide association study (GWAS) data from the FinnGen Biobank.
  • Analyzed 91 inflammatory proteins and their association with BPH and prostatitis.
  • Performed bidirectional MR and sensitivity analyses to assess causality and rule out bias.

Main Results:

  • Decreased interleukin-17 C (IL-17 C) levels were suggestively linked to higher BPH risk.
  • Elevated interleukin-10 receptor subunit alpha (IL-10RA) and urokinase-type plasminogen activator (uPA) were suggestively associated with higher prostatitis risk.
  • Benign prostatic hyperplasia (BPH) showed potential to increase levels of CD244, CD6, and LIF-R.

Conclusions:

  • Circulating inflammatory proteins show a potential association with benign prostatic disease (BPD).
  • Specific proteins like IL-17 C, IL-10RA, uPA, CD244, CD6, and LIF-R may serve as novel biomarkers or therapeutic targets for BPD.
  • Further research is warranted to validate these findings and explore clinical applications.