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Recommendations for a standardized publication protocol for a QSP model.

Jared Weddell1, Abhishek Gulati2, Akihiro Yamada3

  • 1Early Development, New Technology, Astellas Pharma Inc, Northbrook, IL, USA.

Journal of Pharmacokinetics and Pharmacodynamics
|October 10, 2024
PubMed
Summary
This summary is machine-generated.

Developing Quantitative Systems Pharmacology (QSP) models is challenging due to a lack of standard publishing practices, hindering reproducibility. This study investigates QSP model reproducibility issues and proposes standard practices and a publication protocol to improve knowledge preservation.

Keywords:
MIDDMechanistic modelingQSPReproducibility

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Area of Science:

  • Pharmacology
  • Computational Biology
  • Systems Biology

Background:

  • Quantitative Systems Pharmacology (QSP) model development is an iterative and lengthy process.
  • Limited standard practices for publishing QSP models contribute to significant reproducibility challenges in the field.
  • Previous studies have highlighted model reproducibility as a major hurdle for QSP.

Purpose of the Study:

  • To investigate the root causes of reproducibility issues in Quantitative Systems Pharmacology (QSP) models.
  • To propose standardized practices for QSP model publication to enhance reproducibility.
  • To introduce a protocol for improved QSP model publication strategies to ensure knowledge preservation.

Main Methods:

  • Literature review and analysis of existing QSP modeling and publication practices.
  • Identification of common challenges and contributing factors to QSP model irreproducibility.
  • Development of a proposed set of standard practices and a publication protocol.

Main Results:

  • Lack of standardized reporting and documentation practices identified as key contributors to QSP model irreproducibility.
  • Proposed standard practices address data, code, and model parameter sharing.
  • A detailed publication protocol is suggested to guide authors and journals.

Conclusions:

  • Implementing standard practices and a clear publication protocol is crucial for improving the reproducibility of Quantitative Systems Pharmacology (QSP) models.
  • Adoption of these standards will enhance the reliability and accessibility of QSP research.
  • This work aims to foster better QSP knowledge preservation and facilitate scientific advancement.