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Updated: Jun 10, 2025
Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
Published on: May 31, 2024
Longitudinal outcomes of iStent inject with cataract surgery compared with cataract surgery alone: real-world data
Colin I Clement1, Vuong Nguyen, Frank Howes
1From the Save Sight Institute, University of Sydney, Sydney, Australia (Clement, Nguyen, Gillies, Lawlor); Eye Associates, Sydney, Australia (Clement, Gillies); Eye and Laser Centre, Gold Coast, Australia (Howes); Northern Beaches Cataract Retina Glaucoma, Brookvale, Australia (Danks); South West Eye Surgery, Warrnambool, Australia (Lee); Burwood Eye Surgery, Burwood, Australia (Wechsler); Eye Specialist Practice, Bondi Junction, Australia (Roberts); Sydney Eye Surgeons, Bondi Junction, Australia (Lawlor).
Purpose:
To compare combined phacoemulsification and iStent inject with phacoemulsification alone.
Setting:
Fight Glaucoma Blindness (FGB) registry, Sydney, Australia.
Design:
Prospective observational registry study.
Methods:
Eyes that had combined phacoemulsification with iStent inject (iStent group), n = 1257 were compared with eyes that had phacoemulsification only (cataract alone, n = 163). The primary outcome was percentage of eyes achieving >20% intraocular pressure (IOP) reduction from baseline 12 months postoperatively. Secondary outcomes included mean IOP and medication reduction, adverse events, and secondary procedures.
Results:
At 12 months, the percentage of eyes achieving >20% reduction of IOP was significantly higher in the iStent group compared with the cataract-alone group (40.9% vs 30.1% P < .001). Adverse events occurred at a low rate in both groups, and secondary IOP-lowering procedures were significantly less frequent in the iStent group compared with cataract alone.
Conclusions:
Real-world outcomes from the FGB registry at 12 months show that phacoemulsification combined with iStent inject has a higher efficacy and reduced need for secondary IOP-lowering surgery compared with phacoemulsification alone.
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