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Updated: Jun 10, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

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Mild behavioral impairment in the general population aged 55+ and its association with incident dementia

Patricia Gracia-García1,2,3,4, Raúl López-Antón4,5, Concepción de la Cámara1,3,4,6

  • 1Departamento de Medicina, Psiquiatría y Dermatología, Facultad de Medicina Universidad de Zaragoza Zaragoza Spain.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|October 11, 2024
PubMed

Insights

Mild behavioral impairment (MBI) in older adults may predict dementia risk. Specifically, decreased motivation emerged as a significant indicator for all-cause dementia in community-dwelling individuals.

Area of Science:

  • Gerontology
  • Neuroscience
  • Epidemiology

Background:

  • Mild behavioral impairment (MBI) is increasingly recognized as a potential precursor to dementia.
  • Understanding the specific domains of MBI associated with dementia risk is crucial for early identification.

Purpose of the Study:

  • To investigate the association between mild behavioral impairment (MBI) and its specific domains with the risk of developing dementia.
  • To identify potential phenotypic markers for dementia risk within the MBI spectrum.

Main Methods:

  • Longitudinal study (ZARADEMP) following 4803 community-dwelling individuals aged over 55 for 4.5 years.
  • Assessment of MBI using the Geriatric Mental State (GMS) based on ISTAART criteria.
  • Logistic regression models were used to calculate odds ratios (OR) for incident dementia and Alzheimer's disease (AD), adjusting for confounders.

Main Results:

  • Decreased motivation, a domain of MBI, was significantly associated with an increased risk of all-cause dementia (OR: 2.30 [95% CI: 1.16-4.61]) in cognitively normal individuals.
  • The association between decreased motivation and Alzheimer's disease (AD) risk did not reach statistical significance.
  • Other MBI domains were not significantly associated with increased dementia risk in this cohort.

Conclusions:

  • Decreased motivation may serve as a valuable phenotypic marker for identifying individuals at higher risk of dementia.
  • Further research is warranted to explore the relationship between various MBI domains and specific dementia subtypes.
Keywords:
agingdementiamild behavioral impairmentneuropsychiatric symptomsnon‐cognitive symptoms

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