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A Rare Case of ANCA-negative Rapidly Progressive Glomerulonephritis: A Case Report
Jerry Kenmoe1, Elizabeth Mikhail1, Fahimeh Talaei1
1Department of Internal Medicine, McLaren Health Care/Michigan State University, Flint, MI, USA.
Abstract:
ANCA-negative rapidly progressive glomerulonephritis (RPGN) is a rare condition caused by glomerular injury in the absence of detectable antineutrophil cytoplasmic antibodies (ANCAs). While comprehensive epidemiologic data is limited, ANCA-negative RPGN is known to comprise 5-20% of all glomerulonephritis cases. We report the case of a 43-year-old male who presented to the hospital after a snowmobile accident with symptoms of general malaise along with the emergence of a new-onset rash and tea-colored urine. Further workup with CT-guided kidney biopsy confirmed the diagnosis of RPGN by revealing histopathological findings of crescentic glomerulonephritis and significant glomerular inflammation. Treatment was promptly initiated with prednisone and Cytoxan and the patient was subsequently discharged in stable condition. We aim to enrich the existing literature by describing the clinical presentation, diagnostic workup and management of ANCA-negative RPGN.
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