Comparison of rapid bacteriological response to MT-141 and latamoxef in complicated urinary tract infections

To assess the rapid bactericidal properties of MT-141, a new cephamycin antibiotic, bacteriological response to MT-141 and latamoxef was compared in complicated urinary tract infections. Although MT-141 was less potent in terms of its MICs than latamoxef against bacterial isolates and was eliminated more slowly than latamoxef from the kidney, MT-141 gave a greater rate of decrease in urinary bacterial counts than latamoxef 6 hours after administration.