The antibacterial activity of gentamicin in the glucosuric environment

The antibacterial activity of gentamicin against 10 isolates of E. coli and 10 of P. aeruginosa was investigated in pooled human urine, with or without the addition of 20 g % dextrose, at pH 6. Mean values for T50 under the influence of 50 mg/ml gentamicin were 3 +/- 0.23 h vs 1.86 +/- 0.10 h and 3.5 +/- 0.08 h vs 1.56 +/- 0.13 h with an osmolality of 1200 mosm/l and 820 mosm/l respectively.