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Statin Therapy Reduces Radiation-Induced Cardiotoxicity in Patients With Breast Cancer Receiving Adjuvant

Yan-Jiun Huang1,2,3, Jui-An Lin4,5,6,7,8, Wan-Ming Chen9,10

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Statin therapy significantly lowers major adverse cardiovascular event (MACE) risk in breast cancer patients after surgery and radiotherapy. Hydrophilic statins like rosuvastatin and pravastatin offer the most protection, showing a dose-response benefit.

Keywords:
breast cancerdose–response relationshipsradiation therapyradiation‐induced MACEstatin therapy

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Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Breast cancer survivors undergoing breast-conserving surgery and radiotherapy face increased cardiovascular risk.
  • Major adverse cardiovascular events (MACE) are a significant concern in this patient population.

Purpose of the Study:

  • To evaluate the cardioprotective efficacy of statin therapy in reducing MACE risk.
  • To identify specific statin types and dosages associated with the greatest risk reduction.

Main Methods:

  • Retrospective cohort study using Taiwan Cancer Registry and National Health Insurance Research Databases.
  • Propensity score matching to compare MACE risk between statin users and nonusers.
  • Cox regression models to analyze adjusted hazard ratios (aHRs) and dose-response relationships.

Main Results:

  • Statin use significantly reduced MACE risk by 66% (aHR, 0.34 [95% CI, 0.25-0.44]).
  • Hydrophilic statins, particularly rosuvastatin and pravastatin, showed the most significant risk reduction.
  • A dose-response relationship was observed, with higher statin doses correlating with lower MACE risk.

Conclusions:

  • Statin therapy is effective in mitigating MACE risk for breast cancer patients post-surgery and radiotherapy.
  • Rosuvastatin and pravastatin demonstrate pronounced cardioprotective effects.
  • Further research is warranted to optimize statin use in breast cancer survivors to prevent cardiovascular complications.