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Updated: Jun 10, 2025

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Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival
Ethan L Morgan1,2, Anthony D Saleh1, Shaleeka Cornelius1
1Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.
Cancer Research Communications
|October 11, 2024
Abstract
Significance:
Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.
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