Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

1.3K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.3K
Endocarditis II: Clinical features and Diagnostic Tests01:25

Endocarditis II: Clinical features and Diagnostic Tests

2
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

2
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

3
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
3
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.0K
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

2
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
2

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS-DAI).

Arthritis care & research·2026
Same author

Illustrative Integration of Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Data in Dose-Cohort Review for a Phase I Clinical Trial.

Research square·2026
Same author

Comparative Efficacy of Topical Anesthetic Compounds Prior to 1927-nm Fractional Thulium Fiber Laser.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Advancing Pulmonary Fibrosis Care: Integrating Genomic Insights Into Clinical Practice.

Mayo Clinic proceedings·2026
Same author

In Reply.

Archives of pathology & laboratory medicine·2026
Same author

Extended Cancer Spectrum in Adults With Telomere Biology Disorders: Insights From a 113-Patient Single-Center Cohort.

American journal of hematology·2026

Related Experiment Video

Updated: Jun 10, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:37

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

266

Vasculitis associated with VEXAS syndrome.

Megan Sullivan1, Carolyn Mead-Harvey2, Julio C Sartori-Valinotti3

  • 1Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Rheumatology (Oxford, England)
|October 11, 2024
PubMed
Summary

A quarter of patients with VEXAS syndrome develop vasculitis, commonly affecting small and medium vessels. Cranial symptoms can occur, but large vessel inflammation is rare in this condition.

Keywords:
UBA1 mutationVEXAS syndromeautoinflammatory diseasegiant cell arteritissomatic mutationvascular inflammationvasculitis

More Related Videos

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups
10:35

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Published on: January 12, 2020

8.5K
Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
07:05

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy

Published on: September 27, 2024

414

Related Experiment Videos

Last Updated: Jun 10, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:37

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

266
Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups
10:35

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Published on: January 12, 2020

8.5K
Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
07:05

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy

Published on: September 27, 2024

414

Area of Science:

  • Rheumatology
  • Genetics
  • Immunology

Background:

  • VEXAS (vacuoles, E1-enzyme, X-linked, autoinflammation, somatic) syndrome is a recently identified autoinflammatory condition.
  • Understanding the spectrum of VEXAS syndrome, particularly its association with vasculitis, is crucial for diagnosis and management.

Purpose of the Study:

  • To determine the prevalence, distribution, and characteristics of vasculitis in patients with VEXAS syndrome.
  • To characterize the types and clinical manifestations of vasculitis associated with VEXAS syndrome.

Main Methods:

  • Retrospective chart review of 89 male patients with confirmed UBA1 mutations.
  • Vasculitis diagnosis based on histopathology or non-invasive angiography.
  • Analysis of patient demographics, clinical features, and outcomes.

Main Results:

  • 23.6% of VEXAS patients (21/89) exhibited vasculitis.
  • Small vessel vasculitis (19.1%) was most common, often cutaneous leukocytoclastic vasculitis.
  • Cranial symptoms occurred in 18.0%, and large vessel involvement was rare.

Conclusions:

  • VEXAS syndrome presents with variable vasculitis in approximately a quarter of affected individuals.
  • Cutaneous small and medium vessel vasculitis are frequent manifestations.
  • Cranial symptoms may mimic other conditions like GCA, necessitating careful evaluation.