Salvage Surgery for Unifocal Progressive Metastatic Mismatch Repair-Deficient GI Cancer Responding to Immune...

Area of Science:

• Oncology
• Gastroenterology
• Immunotherapy

Background:

• Mismatch repair deficient (dMMR) gastrointestinal (GI) cancers represent a distinct molecular subtype.
• Immunotherapy has revolutionized cancer treatment, particularly for dMMR tumors.
• The management of oligoprogression during immunotherapy requires careful consideration.

Purpose of the Study:

• To describe outcomes in patients with dMMR GI cancer experiencing oligoprogression during immunotherapy.
• To evaluate the impact of surgical resection of a single progressive lesion in this context.

Main Methods:

• A case series approach was utilized.
• Data were collected retrospectively on patients with dMMR GI cancer treated with immunotherapy.
• Patients who developed a single progressive lesion and underwent resection were analyzed.

Main Results:

• Patients who underwent resection of a single progressive lesion demonstrated excellent outcomes.
• No further progression or recurrence was observed in the resected lesion sites.
• Durable responses to immunotherapy were maintained post-resection.

Conclusions:

• Resection of a single progressive lesion in dMMR GI cancer patients undergoing immunotherapy is a viable strategy.
• This approach may allow for continued immunotherapy and favorable long-term outcomes.
• Further prospective studies are warranted to confirm these findings.